• Our results show furthermore that higher concentrations of

  2022-07-22

  

  Our results show furthermore, that higher concentrations of butyric BTS additionally affect GSTP1 mRNA stability leading to a strongly reduced half-life. Concentration-dependent effects of butyric acid on RNA stability and cell signaling pathways involved in the regulation of GSTP1 expression remai

• br Conclusion In this report we describe

  2022-07-22

  

  Conclusion In this report, we describe the synthesis and evaluation of oxadiazole-based GSK3 inhibitors. Occupation of the ATP-binding pocket in its entirety led to the identification of several potent and selective compounds. These compounds are characterized by IC50 values in the low nanomolar

• br Ketone body metabolism and neuronal

  2022-07-22

  

  Ketone body metabolism and neuronal excitability One of the best examples of the close connection between metabolism and neuronal excitability is illustrated by the effect of ketone bodies on epileptic seizures. One third of patients suffering from epileptic seizures do not respond to conventiona

• To verify the feasibility of the

  2022-07-21

  

  To verify the feasibility of the proposed method, EIS is firstly adopted to study the modification processes of the electrode. As shown in Fig. 1A, the nyquist plot of bare gold electrode exhibits a straight line, which indicates a fast charge transfer process (curve a). After modified with probe a,

• br Discussion Agonist and antagonist

  2022-07-21

  

  Discussion Agonist and antagonist action at the GluN1/GluN3 Bleomycin A5 hydrochloride is known to be complex [4], [10]. Recombinant GluN1/GluN3 receptors produce only small excitatory currents in response to glycine, likely because of a combination of activation via GluN3 and desensitization vi

• br Author s contributions br Conflict of interest

  2022-07-21

  

  Author's contributions Conflict of interest Acknowledgements This work was supported in part by a grant from Department of Biotechnology (DBT), Government of India (Sanction Order No.: BT/563/NE/U-Excel/2016). MC, PDG and SKM acknowledge the Ministry of Human Resource and Development (MHRD)

• Interestingly mGlu and mGlu receptors differ notably by thei

  2022-07-21

  

  Interestingly, mGlu2 and mGlu3 receptors differ notably by their cellular distribution. Whereas mGlu2 receptors are mostly neuronal, mGlu3 receptors are expressed both in glia and in neurons. In neurons, mGlu3 receptors are present at the post-synapse and in presynaptic elements (Tamaru et al., 2001

• In contrast to short term

  2022-07-21

  

  In contrast to short-term effects, long-term exposure of beta cells to FFAs impairs insulin secretion and triggers apoptosis [13]. The deleterious effects of FFAs have been linked to altered glucose/fatty Sodium Picosulfate oxidation cycle [13], decreased NADPH content [14], endoplasmic reticulum (E

• The unique mechanism of EAAT anion

  2022-07-21

  

  The unique mechanism of EAAT anion channel gating results in neuronal or glial anion conductances that follow changes in substrate concentrations and thus allow feedback control of glutamate release (Wersinger et al., 2006) or modification of GABAergic postsynaptic currents by glutamatergic signals

• br Conclusions br Acknowledgement Work in the authors labs w

  2022-07-21

  

  Conclusions Acknowledgement Work in the authors’ labs was funded by Natural Sciences and Engineering Research Council of Canada (OGP0194652 and OGP0041653) and Diabète Québec. Introduction Fifty years ago, Sydney Brenner proposed Caenorhabditis elegans as a useful model for the study of an

• With rare exceptions the biological role of secretase cleava

  2022-07-21

  

  With rare exceptions, the biological role of γ-secretase cleavage of substrates other than Notch 1 has been ignored during proof of concept preclinical repurposing studies. For example, in the GSI AD trial, many individuals noted changes in hair color, apparently due to inhibition of tyrosinase, ano

• br Materials and methods br Results Bgal from Alteromonas

  2022-07-21

  

  Materials and methods Results Bgal from Alteromonas sp. ML117 had an open reading frame of 3126 bp encoding 1042 amino CFDA SE Cell Tracer Kit residues with a predicted mass of 120 kDa and a theoretical pI (isoelectric point) of 5.44. The recombinant Bgal contained a His tag, as well as other

• br BA induced activation of

  2022-07-21

  

  BA-induced activation of TGR5 TGR5 is a membrane-bound G protein-coupled receptor for BAs and its activation is dependent on cAMP formation and further stimulation of protein kinase A [53], [31]. The receptor is expressed in the enterochromaffin cells, smooth muscles, immune cells and more import

• Immunohistochemistry using anti FFAR antibodies revealed imm

  2022-07-21

  

  Immunohistochemistry using anti-FFAR1 antibodies revealed immunoreactivity for FFAR1 in association with the cell membrane of the hepatocytes (Figure 2). However, the anti-FFAR2 antibody was not suitable for immunohistochemistry under the tested conditions (data not shown). Fatty liver is an import

• The canonical tumor suppressor p

  2022-07-21

  

  The canonical tumor suppressor p53 has also been implicated as a transcriptional mediator of ferroptotic death (Jiang et al., 2015, Tarangelo et al., 2018, Wang et al., 2016, Xie et al., 2017). Specifically, p53 negatively regulates transcription of SLC7A11, the cystine-glutamate antiporter (Xc-) (J

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