• Using RT PCR we demonstrated the expression

  2021-09-08

  

  Using RT-PCR we demonstrated the expression of GPR55 receptor mRNA in the ileum and colon of mice, which is in good agreement with previous reports (Lin et al., 2011). The quantitative analysis showed the abundance of GPR55 mRNA in the mucosa of the ileum and colon. In contrast, in LMMP preparations

• As part of our discovery efforts

  2021-09-08

  

  As part of our discovery efforts searching for small molecule GPR119 agonists, we analyzed active pharmacophores of known agonists from the literature, and found that -methylsulfonylphenyl and substituted 4-hydroxyl piperidine are common fragments. In our initial efforts, we linked these two fragme

• Extending the issue of the species differences the

  2021-09-08

  

  Extending the issue of the species differences, the role of neuroestradiol in the preovulatory GnRH/LH surge might be specific to primates or species with a luteal phase. For example, animals with a true luteal phase, such as monkeys and sheep, exhibit a long preovulatory GnRH surge, lasting well af

• The study of TcMYH protein

  2021-09-08

  

  The study of TcMYH protein is a step forward for the characterization of a GO system in T. cruzi. The complete system appears to be present and our findings demonstrate that is important to maintain DNA stability of the nuclear and mitochondrial genomes, particularly in the presence of oxidative str

• br Materials and methods E coli strains Strains

  2021-09-08

  

  Materials and methods E. coli strains. Strains of E. coli with mutations in the lacZ gene for β-galactosidase [5] and a derivative with a knock-out mutation of the chromosomal gene for FPG produced with P1vir [6] were obtained from H. Schellhorn (McMaster Univ., Hamilton, Ontario, Canada). Growth

• These differences have led to the

  2021-09-08

  

  These differences have led to the recognition that the extent to which transport contributes to shaping postsynaptic signals likely reflects a balance between the density of transporters and the amount of l-glutamate in the synaptic cleft. Consequently, those synapses exhibiting the characteristics

• Glutamate activates cationic glutamate gated channels i

  2021-09-08

  

  Glutamate activates cationic glutamate-gated channels (i.e. ionotropic glutamate receptors) that mediate the fast excitatory actions of glutamate. It also activate G protein-coupled receptors, named metabotropic glutamate receptors (mGluRs) (Pin and Bettler, 2016). The eight subtypes of mGluRs are k

• Taking into account abovementioned vitamin D deficiency

  2021-09-08

  

  Taking into account abovementioned, vitamin D3 deficiency effects on synaptic neurotransmission can be considered as targeting both Ca2+-independent and Ca2+-dependent processes. Ca2+-independent action of vitamin D3 deficiency is associated with a decrease in the expression of glutamate and GABA tr

• This work was supported by the National Natural Science

  2021-09-08

  

  This work was supported by the National Natural Science Foundation of China (Grants 81471101 and 81870852), the Natural Science Foundation of Jiangsu Province (Grant BK20181146), the Natural Science Foundation of the Jiangsu Higher Education Institutions of China (Grants 18KJA320007 and 17KJB320018)

• br Acknowledgments br Introduction Postmenopausal osteoporos

  2021-09-08

  

  Acknowledgments Introduction Postmenopausal osteoporosis, which is primarily caused by 1295 deficiency, has been a worldwide health problem and threatens postmenopausal women of all races. An estimated 80% of osteoporosis patients in the United States are women, and approximately 30% of postm

• dhfr inhibitors In order to test the influence of

  2021-09-08

  

  In order to test the influence of the initial depolarization, experiments were performed, where the degree of chloride substitution was varied, either by adding n-Ringer to dhfr inhibitors incubated in a sucrose Ringer or by suspending the cells directly in Ringers identical to the final composition

• cyclin dependent kinase inhibitor Piezo channels can be acti

  2021-09-08

  

  Piezo channels can be activated by many mechanical stimuli . While some of these stimulations directly mimic physiological forces experienced by cyclin dependent kinase inhibitor , such as shear stress applied in a microfluidic chamber, the most commonly used modes of stimulation consist of stretchi

• Comparison of dlGALRs deduced amino acid sequences with that

  2021-09-08

  

  Comparison of dlGALRs deduced amino dapagliflozin sequences with that of human GALRs demonstrate that the GALR1 ortholog sequences have diverged less than those of GALR2. Since often duplicate genes undergo divergent evolution through sub-functionalization, loss or gain of new functions (Prince and

• JTC-801 Similar to C lividipennis RDL Jiang et

  2021-09-08

  

  Similar to C. lividipennis RDL (Jiang et al., 2015), we found that the intracellular loop variants of A. mellifera RDL had no effect on GABA EC50 (Table 1). Also, as with C. lividipennis, there was no significant difference in maximal GABA responses (Table 1). However, whereas the 31 amino acid inse

• The diverse biochemistry of zinc means

  2021-09-08

  

  The diverse biochemistry of zinc means that, in many cases, more than one factor (or pathway) is at play. Whilst catalytic Zn2+ sites are now typically well-understood, the recognition that Zn2+ levels regulate the function of many cell types has led to vigorous interest in the fate and role of mobi

16452 records 620/1097 page Previous Next First page 上5页 616617618619620 下5页 Last page